Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.

Article Details

Citation

Letavic MA, Stocking EM, Barbier AJ, Bonaventure P, Boggs JD, Lord B, Miller KL, Wilson SJ, Carruthers NI

Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4799-803. Epub 2007 Jun 26.

PubMed ID
17616397 [ View in PubMed
]
Abstract

The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H(3) ligands that are also serotonin reuptake transporters is described.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
FluoxetineSodium-dependent serotonin transporterKi (nM)2.2N/AN/ADetails