2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).

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Blizzard TA, Morgan JD 2nd, Mosley RT, Birzin ET, Frisch K, Rohrer SP, Hammond ML

2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs).

Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83.

PubMed ID

12565955 [ View in PubMed

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Abstract

A series of 2-phenylspiroindenes was prepared. The most active analogue (2) was found to be comparable in potency to raloxifene (1) as an estrogen receptor ligand.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Raloxifene	Estrogen receptor alpha	IC 50 (nM)	1.8	N/A	N/A	Details
Raloxifene	Estrogen receptor beta	IC 50 (nM)	12	N/A	N/A	Details