Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor alpha and their bioactivities in vivo.
Article Details
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Yang C, Xu G, Li J, Wu X, Liu B, Yan X, Wang M, Xie Y
Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor alpha and their bioactivities in vivo.
Bioorg Med Chem Lett. 2005 Mar 1;15(5):1505-7.
- PubMed ID
- 15713417 [ View in PubMed]
- Abstract
The synthesis of benzothiophenes containing a piperazine side chain and their binding affinities for estrogen receptors are described. These compounds bearing piperazine side chains were identified to be high-affinity ligands with high selectivity for ER alpha subtype. They were also potent agonists in bone tissue.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Raloxifene Estrogen receptor alpha IC 50 (nM) 0.73 N/A N/A Details Raloxifene Estrogen receptor beta IC 50 (nM) 18.9 N/A N/A Details