Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators.

Article Details

Citation

Ji Q, Gao J, Wang J, Yang C, Hui X, Yan X, Wu X, Xie Y, Wang MW

Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators.

Bioorg Med Chem Lett. 2005 Jun 2;15(11):2891-3.

PubMed ID
15911274 [ View in PubMed
]
Abstract

A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ERalpha and ERbeta) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
RaloxifeneEstrogen receptor alphaIC 50 (nM)0.89N/AN/ADetails
RaloxifeneEstrogen receptor betaIC 50 (nM)1.6N/AN/ADetails