Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors.
Article Details
- CitationCopy to clipboard
Rahim MA, Rao PN, Knaus EE
Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors.
Bioorg Med Chem Lett. 2002 Oct 7;12(19):2753-6.
- PubMed ID
- 12217369 [ View in PubMed]
- Abstract
A group of isomers possessing a 2-, 3-, or 4-acetoxy moiety on the 3-phenyl substituent of rofecoxib were synthesized that exhibit highly potent, and selective, COX-2 inhibitory activity that have the potential to acetylate the COX-2 isozyme.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Celecoxib Prostaglandin G/H synthase 2 IC 50 (nM) 56.7 N/A N/A Details Rofecoxib Prostaglandin G/H synthase 2 IC 50 (nM) 427.9 N/A N/A Details