Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors.

Article Details

Citation

Rahim MA, Rao PN, Knaus EE

Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors.

Bioorg Med Chem Lett. 2002 Oct 7;12(19):2753-6.

PubMed ID
12217369 [ View in PubMed
]
Abstract

A group of isomers possessing a 2-, 3-, or 4-acetoxy moiety on the 3-phenyl substituent of rofecoxib were synthesized that exhibit highly potent, and selective, COX-2 inhibitory activity that have the potential to acetylate the COX-2 isozyme.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
CelecoxibProstaglandin G/H synthase 2IC 50 (nM)56.7N/AN/ADetails
RofecoxibProstaglandin G/H synthase 2IC 50 (nM)427.9N/AN/ADetails