Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum.

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Zou J, Jin D, Chen W, Wang J, Liu Q, Zhu X, Zhao W

Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum.

J Nat Prod. 2005 Oct;68(10):1514-8.

PubMed ID

16252917 [ View in PubMed

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Abstract

Chemical investigation of the anti-inflammatory Chinese folk medicine Calophyllum membranaceum has resulted in the isolation and characterization of three new xanthones (1-3), one new biphenyl C-glycoside (4), and one new phenylethanoid glycoside (5) along with 17 known compounds. Their structures were characterized on the basis of spectroscopic and chemical methods. Two xanthones, 2,6-dihydroxy-1,7-dimethoxyxanthone (1) and 3,4-dihydroxyxanthone, were found to exhibit selective inhibitory activity against cyclooxygenase-2 (IC(50)=2.99 and 1.80 microM) in vitro.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Celecoxib	Prostaglandin G/H synthase 2	IC 50 (nM)	80	N/A	N/A	Details
Diclofenac	Prostaglandin G/H synthase 2	IC 50 (nM)	70	N/A	N/A	Details