Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum.
Article Details
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Zou J, Jin D, Chen W, Wang J, Liu Q, Zhu X, Zhao W
Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum.
J Nat Prod. 2005 Oct;68(10):1514-8.
- PubMed ID
- 16252917 [ View in PubMed]
- Abstract
Chemical investigation of the anti-inflammatory Chinese folk medicine Calophyllum membranaceum has resulted in the isolation and characterization of three new xanthones (1-3), one new biphenyl C-glycoside (4), and one new phenylethanoid glycoside (5) along with 17 known compounds. Their structures were characterized on the basis of spectroscopic and chemical methods. Two xanthones, 2,6-dihydroxy-1,7-dimethoxyxanthone (1) and 3,4-dihydroxyxanthone, were found to exhibit selective inhibitory activity against cyclooxygenase-2 (IC(50)=2.99 and 1.80 microM) in vitro.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Celecoxib Prostaglandin G/H synthase 2 IC 50 (nM) 80 N/A N/A Details Diclofenac Prostaglandin G/H synthase 2 IC 50 (nM) 70 N/A N/A Details