Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.
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Zarghi A, Najafnia L, Daraee B, Dadrass OG, Hedayati M
Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.
Bioorg Med Chem Lett. 2007 Oct 15;17(20):5634-7. Epub 2007 Aug 22.
- PubMed ID
- 17822894 [ View in PubMed]
- Abstract
A group of 2,3-diaryl-1,3-thiazolidine-4-ones, possessing a methylsulfonyl pharmacophore, were synthesized and their biological activities were evaluated for cyclooxygenase-2 (COX-2) inhibitory activity.
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Celecoxib Prostaglandin G/H synthase 2 IC 50 (nM) 60 N/A N/A Details