Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.

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Citation

Zarghi A, Najafnia L, Daraee B, Dadrass OG, Hedayati M

Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5634-7. Epub 2007 Aug 22.

PubMed ID
17822894 [ View in PubMed
]
Abstract

A group of 2,3-diaryl-1,3-thiazolidine-4-ones, possessing a methylsulfonyl pharmacophore, were synthesized and their biological activities were evaluated for cyclooxygenase-2 (COX-2) inhibitory activity.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
CelecoxibProstaglandin G/H synthase 2IC 50 (nM)60N/AN/ADetails