Arylpiperazines with N-acylated amino acids as 5-HT1A receptor ligands.

Article Details

Citation

Zajdel P, Subra G, Bojarski AJ, Duszynska B, Pawlowski M, Martinez J

Arylpiperazines with N-acylated amino acids as 5-HT1A receptor ligands.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3406-10. Epub 2006 May 3.

PubMed ID
16677812 [ View in PubMed
]
Abstract

A library consisting of 60 arylpiperazines modified with N-acylated amino acids was prepared on BAL linker SynPhasetrade mark Lanterns and evaluated in vitro for 5-HT(1A) receptor affinity. Biological screening, followed by a simple Fujita-Ban analysis, enabled the description of structure-activity relationships and allowed the selection of some potent, high-affinity ligands for in vivo pharmacological investigations.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
Buspirone5-hydroxytryptamine receptor 1AKi (nM)17N/AN/ADetails