N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.
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Fujio M, Togo Y, Tomozane H, Kuroita T, Morio Y, Katayama J, Matsumoto Y
N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.
Bioorg Med Chem Lett. 2000 Mar 6;10(5):509-12.
- PubMed ID
- 10743959 [ View in PubMed]
- Abstract
A series of benzamides was synthesized as selective agonists for the 5-HT1A receptor. It was found that (S)-N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarb oxamide(7-(S)) has potent and selective agonistic activity for the 5-HT1A receptor (5-HT1A; Ki 0.49 nmol/L, D2; IC50 = >1000 nmol/L, 5-HT2; Ki = 240 nmol/L).
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Haloperidol Dopamine D2 receptor Ki (nM) 1.5 N/A N/A Details