Bioactive sulfoximines: syntheses and properties of Vioxx analogs.

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Park SJ, Buschmann H, Bolm C

Bioactive sulfoximines: syntheses and properties of Vioxx analogs.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4888-90. doi: 10.1016/j.bmcl.2011.06.029. Epub 2011 Jun 22.

PubMed ID

21752640 [ View in PubMed

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Abstract

The syntheses and biological profiles of sulfoximine-based Vioxx analogs 2 are described. Interesting data have been obtained for 2a, which shows a selective COX-2 inhibition (albeit not as strong as Vioxx itself) exhibiting reduced hERG activity compare to the parent sulfone Vioxx (1).

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Rofecoxib	Prostaglandin G/H synthase 2	IC 50 (nM)	156	N/A	N/A	Details