Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.
Article Details
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Chambers RJ, Antognoli GW, Cheng JB, Kuperman AV, Liston TC, Marfat A, Owens BS, Pillar JS, Shirley JT, Watson JW
Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.
Bioorg Med Chem Lett. 1998 Dec 15;8(24):3577-82.
- PubMed ID
- 9934474 [ View in PubMed]
- Abstract
A new series of cysLT1 receptor antagonists represented by CP-288,886 (7) and CP-265,298 (8) were developed which are equipotent to clinical cysLT1 receptor antagonists Zafirlukast (1) and Pranlukast (2).
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Zafirlukast Cysteinyl leukotriene receptor 1 Ki (nM) 2 N/A N/A Details