Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.

Article Details

Citation

Chambers RJ, Antognoli GW, Cheng JB, Kuperman AV, Liston TC, Marfat A, Owens BS, Pillar JS, Shirley JT, Watson JW

Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3577-82.

PubMed ID
9934474 [ View in PubMed
]
Abstract

A new series of cysLT1 receptor antagonists represented by CP-288,886 (7) and CP-265,298 (8) were developed which are equipotent to clinical cysLT1 receptor antagonists Zafirlukast (1) and Pranlukast (2).

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
ZafirlukastCysteinyl leukotriene receptor 1Ki (nM)2N/AN/ADetails