Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.

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Erhardt PW, Woo CM, Anderson WG, Gorczynski RJ

Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.

J Med Chem. 1982 Dec;25(12):1408-12.

PubMed ID

6130154 [ View in PubMed

]

Abstract

Several short-acting beta-adrenergic receptor blocking agents have been prepared by incorporating ester functions into the aryl portion of certain (aryloxy)propanolamine systems. In particular, methyl 3-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]propionate hydrochloride (ASL-8052) was found to be a moderately potent, cardioselective compound with a short duration of action when determined in in vivo canine models.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Practolol	Beta-1 adrenergic receptor	Kd (nM)	251.19	N/A	N/A	Details
Propranolol	Beta-1 adrenergic receptor	Kd (nM)	2	N/A	N/A	Details