Exploring activity cliffs in medicinal chemistry.
Article Details
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Stumpfe D, Bajorath J
Exploring activity cliffs in medicinal chemistry.
J Med Chem. 2012 Apr 12;55(7):2932-42. doi: 10.1021/jm201706b. Epub 2012 Jan 27.
- PubMed ID
- 22236250 [ View in PubMed]
- Abstract
Not Available
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Diclofenac Prostaglandin G/H synthase 1 IC 50 (nM) 3 N/A N/A Details Diclofenac Prostaglandin G/H synthase 2 IC 50 (nM) 5 N/A N/A Details Lumiracoxib Prostaglandin G/H synthase 1 IC 50 (nM) 7 N/A N/A Details Lumiracoxib Prostaglandin G/H synthase 2 IC 50 (nM) >10000 N/A N/A Details