New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics.

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Hauck SI, Cederberg C, Doucette A, Grosser L, Hales NJ, Poon G, Gravestock MB

New carbon-linked azole oxazolidinones with improved potency and pharmacokinetics.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):337-40. Epub 2006 Oct 26.

PubMed ID

17095223 [ View in PubMed

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Abstract

Substitution of phenyl oxazolidinones with carbon-linked azoles resulted in the discovery of a new class of potent oxazolidinones that have excellent Gram-positive activity. In addition, replacement of the C-5 acetamide side chains with a 4-methyl triazole diminished monoamine oxidase activity. The synthesis and biological evaluation of these compounds are reported.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Linezolid	Amine oxidase [flavin-containing] A	Ki (nM)	20000	N/A	N/A	Details