5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine.
Article Details
- CitationCopy to clipboard
Meng CQ, Rakhit S, Lee DK, Kamboj R, McCallum KL, Mazzocco L, Dyne K, Slassi A
5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine.
Bioorg Med Chem Lett. 2000 May 1;10(9):903-5.
- PubMed ID
- 10853656 [ View in PubMed]
- Abstract
A series of 5-(2- or 3-thienyl)tryptamine derivatives (9) has been synthesized and shown to be potent and selective 5-HT1D versus 5-HT1B receptor agonists and, therefore, potential treatments for migraine.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Sumatriptan 5-hydroxytryptamine receptor 1B Ki (nM) 36 N/A N/A Details Sumatriptan 5-hydroxytryptamine receptor 1D Ki (nM) 11 N/A N/A Details