(R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indol e derivatives as high affinity h5-HT1B/1D ligands.

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Egle I, MacLean N, Demchyshyn L, Edwards L, Slassi A, Tehim A

(R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indol e derivatives as high affinity h5-HT1B/1D ligands.

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3419-21.

PubMed ID

14505640 [ View in PubMed

]

Abstract

A series of (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indol e derivatives (2) have been prepared using parallel synthesis, and their structure-activity relationship studied. High affinity human 5-HT(1B/1D) (h5-HT(1B/1D)) ligands have been identified.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Sumatriptan	5-hydroxytryptamine receptor 1B	Ki (nM)	7.7	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1D	Ki (nM)	3.4	N/A	N/A	Details