Isoquinoline derivatives as potential acetylcholinesterase inhibitors.

Article Details

Citation

Copy to clipboard

Markmee S, Ruchirawat S, Prachyawarakorn V, Ingkaninan K, Khorana N

Isoquinoline derivatives as potential acetylcholinesterase inhibitors.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2170-2. Epub 2006 Feb 17.

PubMed ID

16483771 [ View in PubMed

]

Abstract

Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Galantamine	Acetylcholinesterase	IC 50 (nM)	590	N/A	N/A	Details