Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana.

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Devkota KP, Lenta BN, Wansi JD, Choudhary MI, Kisangau DP, Naz Q, Samreen, Sewald N

Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana.

J Nat Prod. 2008 Aug;71(8):1481-4. doi: 10.1021/np800305b. Epub 2008 Aug 6.

PubMed ID

18681480 [ View in PubMed

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Abstract

The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5alpha-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known compounds (3-10). The structures of 1 and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase (IC 50 8.1-48.5 microM) and butyrylcholinesterase (IC 50 0.4-4.0 microM). Compounds 1-10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida.

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Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Galantamine	Acetylcholinesterase	IC 50 (nM)	500	N/A	N/A	Details