Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.

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Ertas A, Ozturk M, Boga M, Topcu G

Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.

J Nat Prod. 2009 Mar 27;72(3):500-2. doi: 10.1021/np800671p.

PubMed ID
19215141 [ View in PubMed
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Abstract

The petroleum ether and acetone extracts of the aerial parts of Sideritis arguta afforded two new and six known diterpenoids with the ent-kaurane skeleton. The structures of the new diterpenoids were determined as ent-7alpha,18-diacetoxy-16beta-hydroxykaurane (diacetyldistanol) (1) and ent-7alpha-acetoxy,15alpha,18-dihydroxykaur-16-ene (15-epi-eubol) (2) by spectroscopic data interpretation. Antioxidant potential was investigated for the ent-kauranes and the plant extracts by three methods (beta-carotene bleaching, free-radical scavenging, and superoxide-anion scavenging activity). Acetylcholinesterase and butyrylcholinesterase inhibitory activity were also evaluated, and the ent-kauranes eubol (3), sideroxol (5), and 7-epi-candicandiol (6) exhibited moderate butyrylcholinesterase inhibitory activity.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
GalantamineAcetylcholinesteraseIC 50 (nM)73900N/AN/ADetails