Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.

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Ohlendorf B, Schulz D, Erhard A, Nagel K, Imhoff JF

Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.

J Nat Prod. 2012 Jul 27;75(7):1400-4. doi: 10.1021/np2009626. Epub 2012 Jul 9.

PubMed ID

22775474 [ View in PubMed

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Abstract

Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data. 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Galantamine	Acetylcholinesterase	IC 50 (nM)	1000	N/A	N/A	Details
Huperzine A	Acetylcholinesterase	IC 50 (nM)	12	N/A	N/A	Details