Wake promoting agents: search for next generation modafinil, lessons learned: part III.

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Dunn D, Hostetler G, Iqbal M, Marcy VR, Lin YG, Jones B, Aimone LD, Gruner J, Ator MA, Bacon ER, Chatterjee S

Wake promoting agents: search for next generation modafinil, lessons learned: part III.

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3751-3. doi: 10.1016/j.bmcl.2012.04.031. Epub 2012 Apr 13.

PubMed ID

22546675 [ View in PubMed

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Abstract

In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Modafinil	Cytochrome P450 2C19	IC 50 (nM)	11000	N/A	N/A	Details