Wake-promoting agents: search for next generation modafinil: part IV.

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Louvet P, Schweizer D, Gourdel ME, Riguet E, Yue C, Marcy VR, Lin YG, Gruner J, Lesur B, Bacon ER, Chatterjee S

Wake-promoting agents: search for next generation modafinil: part IV.

Eur J Med Chem. 2012 Aug;54:949-51. doi: 10.1016/j.ejmech.2012.05.038. Epub 2012 Jun 8.

PubMed ID

22749190 [ View in PubMed

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Abstract

In search of a next generation molecule to the novel wake promoting agent modafinil, a series of diphenyl ether derived wakefulness enhancing agents (in rat) was developed. From this work, racemic compound 16 was separated into its chiral enantiomers to profile them individually.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Modafinil	Cytochrome P450 2C19	IC 50 (nM)	11000	N/A	N/A	Details