Wake-promoting agents: search for next generation modafinil: part IV.

Article Details

Citation

Louvet P, Schweizer D, Gourdel ME, Riguet E, Yue C, Marcy VR, Lin YG, Gruner J, Lesur B, Bacon ER, Chatterjee S

Wake-promoting agents: search for next generation modafinil: part IV.

Eur J Med Chem. 2012 Aug;54:949-51. doi: 10.1016/j.ejmech.2012.05.038. Epub 2012 Jun 8.

PubMed ID
22749190 [ View in PubMed
]
Abstract

In search of a next generation molecule to the novel wake promoting agent modafinil, a series of diphenyl ether derived wakefulness enhancing agents (in rat) was developed. From this work, racemic compound 16 was separated into its chiral enantiomers to profile them individually.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
ModafinilCytochrome P450 2C19IC 50 (nM)11000N/AN/ADetails