Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.

Article Details

Citation

Hanessian S, Bouzbouz S, Boudon A, Tucker GC, Peyroulan D

Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.

Bioorg Med Chem Lett. 1999 Jun 21;9(12):1691-6.

PubMed ID
10397503 [ View in PubMed
]
Abstract

A series of acyclic hydroxamic acids harboring strategically placed alpha-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
Marimastat72 kDa type IV collagenaseIC 50 (nM)2N/AN/ADetails
MarimastatCollagenase 3IC 50 (nM)3.5N/AN/ADetails
MarimastatInterstitial collagenaseIC 50 (nM)1.5N/AN/ADetails
MarimastatMatrix metalloproteinase-9IC 50 (nM)1.5N/AN/ADetails
MarimastatStromelysin-1IC 50 (nM)25N/AN/ADetails