Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.
Article Details
- CitationCopy to clipboard
Hanessian S, Bouzbouz S, Boudon A, Tucker GC, Peyroulan D
Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.
Bioorg Med Chem Lett. 1999 Jun 21;9(12):1691-6.
- PubMed ID
- 10397503 [ View in PubMed]
- Abstract
A series of acyclic hydroxamic acids harboring strategically placed alpha-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Marimastat 72 kDa type IV collagenase IC 50 (nM) 2 N/A N/A Details Marimastat Collagenase 3 IC 50 (nM) 3.5 N/A N/A Details Marimastat Interstitial collagenase IC 50 (nM) 1.5 N/A N/A Details Marimastat Matrix metalloproteinase-9 IC 50 (nM) 1.5 N/A N/A Details Marimastat Stromelysin-1 IC 50 (nM) 25 N/A N/A Details