Synthesis and activity of selective MMP inhibitors with an aryl backbone.
Article Details
- CitationCopy to clipboard
Barta TE, Becker DP, Bedell LJ, De Crescenzo GA, McDonald JJ, Munie GE, Rao S, Shieh HS, Stegeman R, Stevens AM, Villamil CI
Synthesis and activity of selective MMP inhibitors with an aryl backbone.
Bioorg Med Chem Lett. 2000 Dec 18;10(24):2815-7.
- PubMed ID
- 11133099 [ View in PubMed]
- Abstract
A series of novel, MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) CTS-1027 Collagenase 3 IC 50 (nM) 0.6 N/A N/A Details Marimastat 72 kDa type IV collagenase IC 50 (nM) 0.75 N/A N/A Details Marimastat Collagenase 3 IC 50 (nM) 2 N/A N/A Details Marimastat Interstitial collagenase IC 50 (nM) 2.9 N/A N/A Details