General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.

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Chollet AM, Le Diguarher T, Murray L, Bertrand M, Tucker GC, Sabatini M, Pierre A, Atassi G, Bonnet J, Casara P

General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.

Bioorg Med Chem Lett. 2001 Feb 12;11(3):295-9.

PubMed ID
11212095 [ View in PubMed
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Abstract

Modulations of alpha and aryl substitutions on 3-aryloxy propionic acid hydroxamates led to novel and potent inhibitors of MMP-2,3,9 and 13, and selectivity versus MMP-1.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamideStromelysin-1IC 50 (nM)47N/AN/ADetails
Marimastat72 kDa type IV collagenaseIC 50 (nM)1.8N/AN/ADetails
MarimastatCollagenase 3IC 50 (nM)3.4N/AN/ADetails
MarimastatInterstitial collagenaseIC 50 (nM)1.5N/AN/ADetails
MarimastatStromelysin-1IC 50 (nM)25N/AN/ADetails