Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.

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Moriyama H, Tsukida T, Inoue Y, Kondo H, Yoshino K, Nishimura S

Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2737-40.

PubMed ID

12873504 [ View in PubMed

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Abstract

In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Marimastat	Interstitial collagenase	Ki (nM)	1.1	N/A	N/A	Details
Marimastat	Stromelysin-1	Ki (nM)	84	N/A	N/A	Details