Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2.

Article Details

Citation

Lazer ES, Sorcek R, Cywin CL, Thome D, Possanza GJ, Graham AG, Churchill L

Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2.

Bioorg Med Chem Lett. 1998 May 19;8(10):1181-6.

PubMed ID
9871731 [ View in PubMed
]
Abstract

A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the carrageenan-induced paw edema model in rats upon oral administration.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
MeloxicamProstaglandin G/H synthase 2IC 50 (nM)160N/AN/ADetails