Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2.
Article Details
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Lazer ES, Sorcek R, Cywin CL, Thome D, Possanza GJ, Graham AG, Churchill L
Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2.
Bioorg Med Chem Lett. 1998 May 19;8(10):1181-6.
- PubMed ID
- 9871731 [ View in PubMed]
- Abstract
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the carrageenan-induced paw edema model in rats upon oral administration.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Meloxicam Prostaglandin G/H synthase 2 IC 50 (nM) 160 N/A N/A Details