Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.
Article Details
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Wiethe RW, Stewart EL, Drewry DH, Gray DW, Mehbob A, Hoekstra WJ
Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.
Bioorg Med Chem Lett. 2006 Jul 15;16(14):3777-9. Epub 2006 May 5.
- PubMed ID
- 16678409 [ View in PubMed]
- Abstract
New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Mifepristone Progesterone receptor IC 50 (nM) 0.25 N/A N/A Details