Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.

Article Details

Citation

Wiethe RW, Stewart EL, Drewry DH, Gray DW, Mehbob A, Hoekstra WJ

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3777-9. Epub 2006 May 5.

PubMed ID
16678409 [ View in PubMed
]
Abstract

New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
MifepristoneProgesterone receptorIC 50 (nM)0.25N/AN/ADetails