Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.

Article Details

Citation

Tu N, Link JT, Sorensen BK, Emery M, Grynfarb M, Goos-Nilsson A, Nguyen B

Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator.

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4179-83.

PubMed ID
15261266 [ View in PubMed
]
Abstract

Bile acid conjugates of a selective nonsteroidal glucocorticoid receptor modulator were prepared and evaluated. Potent GR binding conjugates that showed improved metabolic stability were discovered. However, cellular potency and pharmacokinetics were not substantially improved.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
MifepristoneGlucocorticoid receptorIC 50 (nM)4.8N/AN/ADetails