New analgesic drugs derived from phencyclidine.

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Itzhak Y, Kalir A, Weissman BA, Cohen S

New analgesic drugs derived from phencyclidine.

J Med Chem. 1981 May;24(5):496-9.

PubMed ID

7241506 [ View in PubMed

]

Abstract

Several esters of 1-(1-phenylcyclohexyl)-4-piperidinol (3), 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol (10) and its propionate (11), and 1-(1-phenylcyclohexyl)-4-phenylpiperidine (13) were prepared and characterized. The new compounds, which are derived from phencyclidine, exerted analgesic activity in mice. The most potent is 10, which is twice as active as morphine. The antinociceptive activity of 10, 11, and 13 could be well correlated with their potency in the mouse vas deferens bioassay, and both were completely reversed by naloxone.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Tacrolimus	Peptidyl-prolyl cis-trans isomerase FKBP1A	IC 50 (nM)	1000	N/A	N/A	Details