High-affinity fluorescent ligands for the 5-HT(3) receptor.

Article Details

Citation

Simonin J, Vernekar SK, Thompson AJ, Hothersall JD, Connolly CN, Lummis SC, Lochner M

High-affinity fluorescent ligands for the 5-HT(3) receptor.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1151-5. doi: 10.1016/j.bmcl.2011.11.097. Epub 2011 Dec 1.

PubMed ID
22189135 [ View in PubMed
]
Abstract

The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
Granisetron5-hydroxytryptamine receptor 3AKi (nM)1.45N/AN/ADetails