High-affinity fluorescent ligands for the 5-HT(3) receptor.
Article Details
- CitationCopy to clipboard
Simonin J, Vernekar SK, Thompson AJ, Hothersall JD, Connolly CN, Lummis SC, Lochner M
High-affinity fluorescent ligands for the 5-HT(3) receptor.
Bioorg Med Chem Lett. 2012 Jan 15;22(2):1151-5. doi: 10.1016/j.bmcl.2011.11.097. Epub 2011 Dec 1.
- PubMed ID
- 22189135 [ View in PubMed]
- Abstract
The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Granisetron 5-hydroxytryptamine receptor 3A Ki (nM) 1.45 N/A N/A Details