Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis.

Article Details

Citation

Copy to clipboard

Tezuka Y, Morikawa K, Li F, Auw L, Awale S, Nobukawa T, Kadota S

Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis.

J Nat Prod. 2011 Jan 28;74(1):102-5. doi: 10.1021/np100665j. Epub 2010 Dec 7.

PubMed ID

21138310 [ View in PubMed

]

Abstract

From the aqueous extract of the wood of Taxus yunnanensis, which showed cytochrome P450 3A4 (CYP3A4) inhibition, a new isoflavan [(3S,4R)-4'-hydroxy-6,3'-dimethoxyisoflavan-4-ol (1)], a new degraded lignan [2,3-bis(hydroxymethyl)-7-hydroxy-6-methoxy-1-tetralone (2)], and a new lignan [(7R)-7-hydroxytaxiresinol (3)] were isolated, together with nine known lignans. Among the isolates obtained, alpha-conidendrin (12) showed strong CYP3A4 inhibition with an IC(50) value of 0.2 muM.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Quinidine	Cytochrome P450 2D6	IC 50 (nM)	10	N/A	N/A	Details