The discovery of AZD9164, a novel muscarinic M3 antagonist.

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Mete A, Bowers K, Chevalier E, Donald DK, Edwards H, Escott KJ, Ford R, Grime K, Millichip I, Teobald B, Russell V

The discovery of AZD9164, a novel muscarinic M3 antagonist.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7440-6. doi: 10.1016/j.bmcl.2011.10.002. Epub 2011 Oct 8.

PubMed ID

22047691 [ View in PubMed

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Abstract

The optimization of a new series of muscarinic M(3) antagonists is described, leading to the identification of AZD9164 which was progressed into the clinic for evaluation of its potential as a treatment for COPD.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Glycopyrronium	Muscarinic acetylcholine receptor M2	IC 50 (nM)	0.158	N/A	N/A	Details
Glycopyrronium	Muscarinic acetylcholine receptor M3	IC 50 (nM)	0.251	N/A	N/A	Details