(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).

Article Details

Citation

Michaelides MR, Hong Y, DiDomenico S Jr, Asin KE, Britton DR, Lin CW, Williams M, Shiosaki K

(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).

J Med Chem. 1995 Sep 1;38(18):3445-7.

PubMed ID
7658429 [ View in PubMed
]
Abstract

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DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
DopamineDopamine D1 receptorKi (nM)130N/AN/ADetails
DopamineDopamine D1 receptorEC 50 (nM)100N/AN/ADetails
DopamineDopamine D2 receptorKi (nM)260N/AN/ADetails
DopamineDopamine D2 receptorEC 50 (nM)170N/AN/ADetails