Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.

Article Details

Citation

Copy to clipboard

Pitts WJ, Guo J, Dhar TG, Shen Z, Gu HH, Watterson SH, Bednarz MS, Chen BC, Barrish JC, Bassolino D, Cheney D, Fleener CA, Rouleau KA, Hollenbaugh DL, Iwanowicz EJ

Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2137-40.

PubMed ID

12127522 [ View in PubMed

]

Abstract

A series of novel triazine-based small molecule inhibitors (IV) of inosine monophosphate dehydrogenase was prepared. The synthesis and the structure-activity relationships (SAR) derived from in vitro studies are described.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Mycophenolic acid	Inosine-5'-monophosphate dehydrogenase 2	IC 50 (nM)	15	N/A	N/A	Details