Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.

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Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ

Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.

Bioorg Med Chem Lett. 2003 Feb 10;13(3):543-6.

PubMed ID

12565968 [ View in PubMed

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Abstract

A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Mycophenolic acid	Inosine-5'-monophosphate dehydrogenase 1	IC 50 (nM)	55	N/A	N/A	Details
Mycophenolic acid	Inosine-5'-monophosphate dehydrogenase 2	IC 50 (nM)	14	N/A	N/A	Details