Thalidomide and its analogues as cyclooxygenase inhibitors.
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Noguchi T, Shimazawa R, Nagasawa K, Hashimoto Y
Thalidomide and its analogues as cyclooxygenase inhibitors.
Bioorg Med Chem Lett. 2002 Apr 8;12(7):1043-6.
- PubMed ID
- 11909713 [ View in PubMed]
- Abstract
Thalidomide showed cyclooxygenase (COX)-1/2 inhibitory activity with a potency comparable to that of aspirin. Structural development studies of thalidomide resulted in potent COX-1/2 inhibitors, and COX-1-selective and COX-2-selective inhibitors.