1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists.
Article Details
- CitationCopy to clipboard
Sonda S, Katayama K, Fujio M, Sakashita H, Inaba K, Asano K, Akira T
1,5-Benzodioxepin derivatives as a novel class of muscarinic M3 receptor antagonists.
Bioorg Med Chem Lett. 2007 Feb 15;17(4):925-31. Epub 2006 Nov 22.
- PubMed ID
- 17188867 [ View in PubMed]
- Abstract
The structure-activity relationships of novel 1,5-benzodioxepin derivatives as muscarinic M(1)-M(3) receptor antagonists are reported. Some of these compounds were found to possess high binding affinity for the muscarinic M(3) receptor and potent effect on rhythmic increase in bladder pressure in unanesthetized rats following oral administration. These compounds displayed selectivity for the bladder over the salivary gland.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Oxybutynin Muscarinic acetylcholine receptor M1 Ki (nM) 1 N/A N/A Details Oxybutynin Muscarinic acetylcholine receptor M2 Ki (nM) 8.1 N/A N/A Details Oxybutynin Muscarinic acetylcholine receptor M3 Ki (nM) 0.78 N/A N/A Details