N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide: an orally bioavailable melatonin receptor agonist.

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Sun LQ, Takaki K, Chen J, Iben L, Knipe JO, Pajor L, Mahle CD, Ryan E, Xu C

N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide: an orally bioavailable melatonin receptor agonist.

Bioorg Med Chem Lett. 2004 Oct 18;14(20):5157-60.

PubMed ID

15380218 [ View in PubMed

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Abstract

N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide 3a was synthesized as an orally bioavailable agonist at MT1 and MT2 melatonin receptors with significantly low vasoconstrictive activity.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Melatonin	Melatonin receptor type 1A	Ki (nM)	0.3	N/A	N/A	Details
Melatonin	Melatonin receptor type 1B	Ki (nM)	0.7	N/A	N/A	Details