Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel mu opioid receptor ligands.

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Allen MP, Blake JF, Bryce DK, Haggan ME, Liras S, McLean S, Segelstein BE

Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel mu opioid receptor ligands.

Bioorg Med Chem Lett. 2000 Mar 20;10(6):523-6.

PubMed ID

10741545 [ View in PubMed

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Abstract

3-Amino-3-phenylpropionamide derivatives were produced as small molecule mimics of the cyclic octapeptide octreotide from readily available imine 1. The compounds exhibit high affinity for the mu opioid receptor.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Naloxone	Kappa-type opioid receptor	Ki (nM)	1.2	N/A	N/A	Details