Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity.

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Hanessian S, Reinhold U, Saulnier M, Claridge S

Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity.

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2123-8.

PubMed ID

9873498 [ View in PubMed

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Abstract

A new synthesis of 4,5-methano-L-prolines and the enzymatic activity of the corresponding N-(3-mercapto-2-R-methyl-propionyl) analogs as inhibitors of angiotensin converting enzyme are described.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Captopril	Angiotensin-converting enzyme	IC 50 (nM)	13	N/A	N/A	Details