4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.
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Bakshi RK, Rasmusson GH, Patel GF, Mosley RT, Chang B, Ellsworth K, Harris GS, Tolman RL
4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.
J Med Chem. 1995 Aug 18;38(17):3189-92.
- PubMed ID
- 7650670 [ View in PubMed]
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Finasteride 3-oxo-5-alpha-steroid 4-dehydrogenase 1 IC 50 (nM) 52 N/A N/A Details