4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.

Article Details

Citation

Bakshi RK, Patel GF, Rasmusson GH, Baginsky WF, Cimis G, Ellsworth K, Chang B, Bull H, Tolman RL, Harris GS

4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.

J Med Chem. 1994 Nov 11;37(23):3871-4.

PubMed ID
7966146 [ View in PubMed
]
Abstract

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DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1IC 50 (nM)52N/AN/ADetails