4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.
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Bakshi RK, Patel GF, Rasmusson GH, Baginsky WF, Cimis G, Ellsworth K, Chang B, Bull H, Tolman RL, Harris GS
4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.
J Med Chem. 1994 Nov 11;37(23):3871-4.
- PubMed ID
- 7966146 [ View in PubMed]
- Abstract
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Finasteride 3-oxo-5-alpha-steroid 4-dehydrogenase 1 IC 50 (nM) 52 N/A N/A Details