A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives.

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Fan G, Mar W, Park MK, Choi EW, Kim K, Kim S

A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives.

Bioorg Med Chem Lett. 2001 Sep 3;11(17):2361-3.

PubMed ID
11527731 [ View in PubMed
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Abstract

A series of umbelliferone derivatives was prepared and their 5alpha-reductase type 1 inhibitory activities were evaluated in cell culture systems. Our studies have identified a new series of potent 5alpha-reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated with overproduction of DHT by 5alpha-reductase type 1. The preliminary structure-activity relationship was described to elucidate the essential structural requirements.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1IC 50 (nM)53000N/AN/ADetails