Alkaloids from the Australian rainforest tree Ochrosia moorei.
Article Details
- CitationCopy to clipboard
Carroll AR, Addepalli R, Fechner G, Smith J, Guymer GP, Forster PI, Quinn RJ
Alkaloids from the Australian rainforest tree Ochrosia moorei.
J Nat Prod. 2008 Jun;71(6):1063-5. doi: 10.1021/np070655e. Epub 2008 Apr 16.
- PubMed ID
- 18412397 [ View in PubMed]
- Abstract
High-throughput screening of a plant and marine invertebrate extract library to find natural products that down-regulate expression of pro-inflammatory genes associated with the glucocorticoid receptor ligand complex led to the identification of bioactive CH2Cl 2 extracts from stems and leaves of the Queensland tree Ochrosia moorei. Bioassay-guided purification of the stem extract enabled the isolation of four alkaloids including two new compounds, ochrosamines A (1) and B (2), and the known compounds ellipticine (3) and 9-methoxyellipticine (4). The leaf extract also afforded 3 and 4 as well as apparicine (5) and desoxycordifoline (6). The structures of the two new compounds were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Ellipticine and 9-methoxyellipticine were the most active components, and both displayed IC 50 values of 90 microM. Apparicine and desoxycordifoline were only very weakly active, and ochrosamines A and B were inactive.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Dexamethasone Glucocorticoid receptor IC 50 (nM) 5 N/A N/A Details