Direct renin inhibitors as a new therapy for hypertension.

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Webb RL, Schiering N, Sedrani R, Maibaum J

Direct renin inhibitors as a new therapy for hypertension.

J Med Chem. 2010 Nov 11;53(21):7490-520. doi: 10.1021/jm901885s.

PubMed ID

20731374 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE	Renin	IC 50 (nM)	4000	N/A	N/A	Details
Aliskiren	Renin	IC 50 (nM)	0.6	N/A	N/A	Details
N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE	Renin	IC 50 (nM)	20	N/A	N/A	Details