A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.

Article Details

Citation

Copy to clipboard

Brown PJ, Winegar DA, Plunket KD, Moore LB, Lewis MC, Wilson JG, Sundseth SS, Koble CS, Wu Z, Chapman JM, Lehmann JM, Kliewer SA, Willson TM

A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.

J Med Chem. 1999 Sep 23;42(19):3785-8.

PubMed ID

10508427 [ View in PubMed

]

Abstract

Not Available

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Bezafibrate	Peroxisome proliferator-activated receptor alpha	EC 50 (nM)	50000	N/A	N/A	Details
Bezafibrate	Peroxisome proliferator-activated receptor delta	EC 50 (nM)	20000	N/A	N/A	Details
Bezafibrate	Peroxisome proliferator-activated receptor gamma	EC 50 (nM)	60000	N/A	N/A	Details