Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators.

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Miyachi H, Nomura M, Tanase T, Takahashi Y, Ide T, Tsunoda M, Murakami K, Awano K

Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators.

Bioorg Med Chem Lett. 2002 Jan 7;12(1):77-80.

PubMed ID

11738577 [ View in PubMed

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Abstract

A series of substituted phenylpropanoic acid derivatives was prepared as part of a search for subtype-selective human peroxisome proliferator-activated receptor (PPAR) activators. Structure-activity relationship studies indicated that the substituent at the alpha-position of the carboxyl group plays a key role in determining the potency and the selectivity for PPAR transactivation.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Bezafibrate	Peroxisome proliferator-activated receptor alpha	EC 50 (nM)	>78000	N/A	N/A	Details
Bezafibrate	Peroxisome proliferator-activated receptor gamma	EC 50 (nM)	>137000	N/A	N/A	Details