Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

Article Details

Citation

Copy to clipboard

Maillet EL, Margolskee RF, Mosinger B

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

J Med Chem. 2009 Nov 12;52(21):6931-5. doi: 10.1021/jm900823s.

PubMed ID

19817384 [ View in PubMed

]

Abstract

We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells of gut and pancreas T1R3 contributes to glucose sensing. Thus, certain effects of fibrates in treating hyperlipidemia and type II diabetes may be via actions on T1R3. Likewise, phenoxy herbicides may have adverse metabolic effects in humans that would have gone undetected in studies on rodents.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Bezafibrate	Peroxisome proliferator-activated receptor alpha	EC 50 (nM)	50000	N/A	N/A	Details