Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin.
Article Details
- CitationCopy to clipboard
Osz E, Somsak L, Szilagyi L, Kovacs L, Docsa T, Toth B, Gergely P
Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin.
Bioorg Med Chem Lett. 1999 May 17;9(10):1385-90.
- PubMed ID
- 10360741 [ View in PubMed]
- Abstract
Reaction of C-(1-bromo-1-deoxy-beta-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of D-glucopyanosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 8,9,10-Trihydroxy-7-hydroxymethyl-2-thioxo-6-oxa-1,3-diaza-spiro[4.5]decan-4-one Glycogen phosphorylase, muscle form Ki (nM) 10900 N/A N/A Details 8,9,10-Trihydroxy-7-hydroxymethyl-2-thioxo-6-oxa-1,3-diaza-spiro[4.5]decan-4-one Glycogen phosphorylase, muscle form Ki (nM) 5100 N/A N/A Details Beta-D-Glucopyranose Spirohydantoin Glycogen phosphorylase, muscle form Ki (nM) 105000 N/A N/A Details Beta-D-Glucopyranose Spirohydantoin Glycogen phosphorylase, muscle form Ki (nM) 26000 N/A N/A Details Beta-D-Glucopyranose Spirohydantoin Glycogen phosphorylase, muscle form Ki (nM) 4200 N/A N/A Details